Radiation is frequently used as part of the treatment of cancer. The radiation works by damaging DNA and components of the cell.How can radiation treatment control or cure cancer?

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1. Radiation therapy targets cancer cells by using high-energy particles or waves, such as X-rays, gamma rays, electron beams, or protons.
2. The primary mechanism of action is the induction of DNA damage in cancer cells. Radiation causes breaks in the DNA strands, which can lead to cell death if the damage is not repaired.
3. Cancer cells are generally more susceptible to DNA damage than normal cells because they divide more rapidly and often have defective DNA repair mechanisms.
4. By damaging the DNA of cancer cells, radiation therapy can prevent them from continuing to grow and divide, leading to their eventual death.
5. The goal of radiation therapy is to maximize damage to cancer cells while minimizing exposure and damage to surrounding healthy tissue, often achieved through precise targeting and dosing.

Key Concepts

DNA Damage and Repair

Radiation therapy primarily works by inducing damage to the DNA within cancer cells. This damage can lead to mutations or cell death if the cells are unable to repair the DNA effectively. Normal cells have robust repair mechanisms, but cancer cells often lack these, making them more susceptible to radiation-induced damage.

Cell Cycle and Apoptosis

Cancer cells typically divide more rapidly than normal cells, making them more vulnerable during specific phases of the cell cycle. Radiation can trigger apoptosis, or programmed cell death, in these damaged cells. Understanding the cell cycle helps in timing radiation treatment to maximize its effectiveness against cancer cells.

Targeting Tumor Microenvironment

Radiation therapy not only affects cancer cells but also impacts the tumor microenvironment, which includes surrounding cells, blood vessels, and immune cells. By damaging the supportive structures of the tumor, radiation can inhibit its growth and enhance the effectiveness of other treatments, such as immunotherapy.