Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
4. Genetic Mapping and Linkage
Mapping Genes
3:19 minutes
Problem 33d
Textbook Question
Textbook QuestionDNA sequences for 10 individuals are
Nucleotide Position
1 5 10
Person 1 ...GACCTATTGC...
Person 2 ...GAACTATTGC...
Person 3 ...GACCTTTTGC...
Person 4 ...GACCTATTGC...
Person 5 ...CAACTATTGC...
Person 6 ...GACCTTTTGC...
Person 7 ...CAACTATTGC...
Person 8 ...GACCTATTGC...
Person 9 ...CAACTATTGC...
Person 10 ...GAACTATTGC...
Identify the nucleotide positions of all SNPs (single nucleotide polymorphisms).
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Single Nucleotide Polymorphisms (SNPs)
Single nucleotide polymorphisms (SNPs) are variations at a single position in a DNA sequence among individuals. They occur when a single nucleotide, such as adenine (A), thymine (T), cytosine (C), or guanine (G), is altered. SNPs can affect gene function and contribute to individual differences in traits, disease susceptibility, and response to drugs.
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Nucleotide Position
Nucleotide position refers to the specific location of a nucleotide within a DNA sequence. In the context of SNP analysis, identifying the nucleotide position is crucial for determining where variations occur. This information helps in comparing sequences across different individuals to pinpoint genetic differences.
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DNA Sequence Alignment
DNA sequence alignment is the process of arranging sequences of DNA to identify regions of similarity and difference. This technique is essential for detecting SNPs, as it allows researchers to compare the nucleotide sequences of multiple individuals side by side. By aligning these sequences, one can easily spot variations at specific nucleotide positions.
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