A 2006 genetic study of a large American family (Ikeda et al.,...

Question

A 2006 genetic study of a large American family (Ikeda et al., 2006) identified genetic linkage between DNA markers on chromosome 11 and the gene producing the autosomal dominant neuromuscular disorder spinocerebellar ataxia type 5 (SCA5). The following lod score data are taken from the 2006 study: Theta (θ) Value 0.01 0.05 0.10 0.20 0.30 0.40SCA5 11.02 12.26 11.94 10.04 7.26 3.77 and DNA marker A SCA5 0.35. 0.94. 1.07 0.99 0.75 0.43 and DNA marker B What is the maximum value for each set of lod scores?

Accepted Answer

Hello, everyone and welcome to today's video. So, a genetic study is carried out to determine the genetic linkage between an autosomal dominant neuromuscular disorder producing gene and DNA markers on a specific chromosome. The maximum L O D which is going to stand for logarithm of odds score of value obtained is 0.7. What does this mean? As answer choice? A we have the genetic linkage between the gene and DNA markers is significant as answer choice B we have there is no significant evidence of genetic linkage between the gene and DNA markers. As answer choice C you have the L O D score is too low to draw any conclusions about genetic linkage. And as answer choice D, we have the L 00 D score suggests that the gene and DNA markers are not far apart on the chromosome. Now, in order to solve this problem, we need to understand L O discourse. Now, a core of three or higher is going to suggest strong evidence of genetic linkage while an L O D of three or less is going to suggest weak evidence or no genetic linkage. So we're told here that this core value is 0.7, which is well below three. So there's really weak evidence that there is genetic linkage between the autosomal dominant neuromuscular disorder producing gene and the DNA markers. And therefore the correct answer for this question is going to be answer choice B there is no significant evidence of genetic linkage between the gene and the DNA markers. I really hope this helped and I hope to see you on the next video.

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