Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
21. Population Genetics
Allelic Frequency Changes
2:22 minutes
Problem 12
Textbook Question
Textbook QuestionUnder what circumstances might a lethal dominant allele persist in a population?
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Lethal Dominant Alleles
A lethal dominant allele is a variant of a gene that, when present in a single copy, can cause the death of an organism before it can reproduce. This type of allele typically leads to a phenotype that is detrimental to survival, often resulting in early embryonic lethality. However, if the allele is not expressed until after reproduction, it can persist in the population.
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04:37
Variations on Dominance
Incomplete Penetrance
Incomplete penetrance occurs when not all individuals with a particular genotype express the expected phenotype. In the case of lethal dominant alleles, some carriers may not exhibit the lethal effects due to environmental factors or other genetic interactions, allowing them to survive and reproduce, thus perpetuating the allele in the population.
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Penetrance and Expressivity
Age of Onset
The age of onset refers to the age at which symptoms of a genetic condition appear. If a lethal dominant allele manifests its effects later in life, after the individual has already reproduced, it can continue to be passed on to the next generation. This delay allows the allele to persist in the gene pool despite its lethal nature.
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Pleiotropy
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