Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
13. Gene Regulation in Eukaryotes
Overview of Eukaryotic Gene Regulation
2:43 minutes
Problem 18d
Textbook Question
Textbook QuestionHow are mRNAs stored within the cell in a translationally inactive state, and how can their translation be stimulated?
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
mRNA Storage and Stability
mRNAs are stored in a translationally inactive state through mechanisms such as deadenylation, decapping, and the formation of mRNA-protein complexes. These processes prevent the mRNA from being translated into proteins, allowing the cell to regulate gene expression and respond to environmental changes. The stability of mRNA is crucial for controlling when and how much protein is produced.
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Translational Control Mechanisms
Translational control mechanisms involve various factors that can activate or inhibit the translation of stored mRNAs. This includes the binding of specific proteins or small RNAs that can either promote ribosome assembly or block it. For example, the phosphorylation of translation initiation factors can stimulate the translation of dormant mRNAs when conditions are favorable.
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Translation Termination
Cellular Signaling Pathways
Cellular signaling pathways play a critical role in the stimulation of mRNA translation. These pathways can respond to external signals, such as growth factors or stress, leading to the activation of kinases and other proteins that modify translational machinery. This allows the cell to quickly adapt to changes by translating stored mRNAs into proteins when needed.
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