Suppose a man and a woman are each heterozygous carriers of a mutation causing a fatal hereditary disease not on the RUSP list. Prenatal genetic testing can identify the genotype of a fetus with regard to this disease and can identify fetuses with the disease. What do you think are the three or four most important factors this couple should consider in their decision making about having children?

Key Concepts

Genetic Inheritance

Genetic inheritance refers to the way traits and genetic conditions are passed from parents to offspring. In this case, both parents are heterozygous carriers of a mutation, meaning they each have one normal allele and one mutated allele. This can lead to a 25% chance of having a child affected by the disease if both parents pass on the mutated allele.

Prenatal Genetic Testing

Prenatal genetic testing involves analyzing the genetic makeup of a fetus to identify potential genetic disorders. This testing can provide crucial information about whether the fetus has inherited the mutation causing the hereditary disease, allowing parents to make informed decisions about their pregnancy and potential interventions.

Ethical Considerations

Ethical considerations in genetic decision-making involve weighing the moral implications of choices regarding prenatal testing and potential outcomes. Couples must consider the emotional, social, and ethical ramifications of terminating a pregnancy based on genetic findings, as well as the impact on their family and future children.