In Section 21.10 we briefly discussed the Human Proteome Map (HPM...

Question

In Section 21.10 we briefly discussed the Human Proteome Map (HPM). An interactive Web site for the HPM is available at http://www.humanproteomemap.org. Visit this site, and then answer the questions in parts (a) and (b) and complete part (c).

How many proteins were identified in this project?

Accepted Answer

Hi everyone. Let's get our next question. According to the human proteome map? H P M. What is the approximate number of protein coding genes present in the human genome? So let's recall what a protium is that up here and the protium would be the entire complement of proteins that can be expressed by a cell tissue or organism. So after the human genome was mapped, the next school became to map the human protium. You have all the genes there and the human genome. Well what are all those proteins that are expressed by that genome? And of course we know that's very complicated because at different stages of development, different bodily tissues, different proteins are expressed. You can have things like alternate splicing that allow a single gene region to code for different versions of a protein. So when we look at the website w w w human proteome app dot org, you can look up information on this human proteome app and access it. Um that was mapped in 2014 was when it was first published. And this website tells us that in that map They have over 17,000 genes, that makes up more than 84% of the human protein coding genes. So looking at our answer choices here, we can go ahead and eliminate two million and one million as being way off in terms of scale here and then we have choice B 15,000 choice D 20,000 They have identified 17,000 protein coding genes. Um but it says that this makes about 84%. So the actual number of protein coding genes would be larger than 17,000. So that leads us to choice the approximately 20,000 protein coding genes present in the human genome. And it's a little bit mind boggling to consider from the same website that these 20,000 or so protein coding genes result in 200 over 290,000 peptide sequences that they identified in this project. So that kind of gives a feel for how the number of proteins possible with the different alternate expressions from single genes is quite large. So that's kind of an interesting comparison. But again, according to the human proteome app, what is the approximate number of protein coding genes present in human genome? And we have choice d 20,000. See you in the next video?

In Section 21.10 we briefly discussed the Human Proteome Map (HPM). An interactive Web site for the HPM is available at http://www.humanproteomemap.org. Visit this site, and then answer the questions in parts (a) and (b) and complete part (c). How many proteins were identified in this project?

Key Concepts

Human Proteome Map (HPM)

Proteomics

Protein Identification

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