What is the difference between saying that cancer is inh...

Question

What is the difference between saying that cancer is inherited and saying that the predisposition to cancer is inherited?

Accepted Answer

Welcome back everyone. Here's the next question. Which of the following is not a tumor predisposition syndrome. So let's look at our answer choices here, we'll start with choice a early onset familial breast cancer. And this is a tumor predisposition syndrome, most often due to mutations in the B. R. C. A. One and two genes which does cause a predisposition towards early onset breast cancer as well as early onset ovarian cancer. So this is we're looking for one that is not a tumor predisposition syndrome. So Choice A is not our answer. Choice B is retinoblastoma, and retinoblastoma is caused by a genetic mutation that causes an increased risk of eye cancer at a young age along with several other forms of cancer. So since that's a tumor predisposition syndrome, it's also an honor answer choice C lee from Mountie syndrome. Uh And this is a rare genetic disorder caused by a mutation in the P 53 gene. P 53 being producing a protein that is a tumor suppressor protein. So, as you might expect, a mutation in a tumor suppressor protein uh causes a very high risk of cancer. It causes a 50% chance of cancer before the age of 30 and individuals with the syndrome and a 90% chance of cancer over a lifetime. So choice see also a predisposition syndrome. And so therefore not an answer. So we're down to choice D Bell's palsy. Um that is our answer. Bell's palsy is not a tumor predisposition syndrome. Bell's palsy is a sudden weakness of the muscles on one side of the face and it's not 100% sure what the causes. It's thought that it's caused by the swelling and inflammation of the cranial nerve. But in that case, obviously not a tumor predisposition syndrome doesn't cause any increased risk of cancer. So which of the following is not a tumor predisposition syndrome. And that's choice. D. Bell's palsy. See you in the next video.

What is the difference between saying that cancer is inherited and saying that the predisposition to cancer is inherited?

Key Concepts

Genetic Inheritance

Cancer as a Genetic Disease

Predisposition vs. Direct Inheritance

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