Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
15. Genomes and Genomics
Genomics and Human Medicine
2:56 minutes
Problem 26a
Textbook Question
Textbook QuestionCraig Venter and others have constructed synthetic copies of viral genomes. For example, the genome for poliovirus and the 1918 influenza strain responsible for the pandemic flu have been assembled this way. The United States currently has a moratorium on federal funding for 'gain-of-function' experiments which increase the virulence or transmission potential of viruses. What concerns might ethicists have about synthetic biology studies involving potential pandemic pathogens?
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Synthetic Biology
Synthetic biology is an interdisciplinary field that combines biology and engineering to design and construct new biological parts, devices, and systems. It involves the manipulation of genetic material to create organisms with desired traits or functions. This technology has significant potential for applications in medicine, agriculture, and environmental science, but it also raises ethical concerns, particularly when it involves pathogens.
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Gain-of-Function Research
Gain-of-function research refers to experiments that enhance the biological functions of an organism, such as increasing its virulence or transmissibility. While this research can provide valuable insights into disease mechanisms and inform public health responses, it poses risks of accidental release or misuse, leading to potential outbreaks of enhanced pathogens. Ethical debates focus on balancing scientific advancement with safety and public health.
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Ethical Implications of Pathogen Research
The ethical implications of research involving potential pandemic pathogens include concerns about biosafety, biosecurity, and the moral responsibilities of scientists. Ethicists worry that creating or enhancing viruses could lead to unintended consequences, such as a pandemic outbreak. Additionally, there are questions about the governance of such research, informed consent, and the potential for dual-use, where research intended for good could be misused for harmful purposes.
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