A developmental disorder in humans called spina bifida is a neural tube defect linked to a maternal diet low in folate during pregnancy.

Should researchers be looking for mutant alleles of genes that control formation and differentiation of the neural tube?

Key Concepts

Neural Tube Development

The neural tube is a structure in the early embryo that eventually develops into the brain and spinal cord. Proper formation and closure of the neural tube are critical for normal central nervous system development. Defects in this process can lead to conditions like spina bifida, where the neural tube fails to close completely.

Folate and Its Role in Development

Folate, or vitamin B9, is essential for DNA synthesis, repair, and methylation, making it crucial during periods of rapid cell division and growth, such as pregnancy. A maternal diet low in folate has been linked to an increased risk of neural tube defects, highlighting the importance of adequate folate intake for fetal development.

Genetic Mutations and Alleles

Mutant alleles are variations of genes that can lead to altered functions or traits. In the context of neural tube defects, researchers may investigate specific genes involved in neural tube formation to identify any mutations that could contribute to conditions like spina bifida. Understanding these genetic factors can help in developing preventive strategies.