Evaluate the following pedigree, and answer the questions below. Calculate F for any inbred members of this family.

Key Concepts

Inbreeding Coefficient (F)

The inbreeding coefficient (F) quantifies the probability that two alleles at a locus in an individual are identical by descent. It is calculated based on the pedigree of the individual, considering the relatedness of the ancestors. A higher F value indicates a greater degree of inbreeding, which can lead to an increased risk of genetic disorders due to the expression of deleterious recessive alleles.

Pedigree Analysis

Pedigree analysis is a method used to study the inheritance patterns of traits across generations in a family. It involves constructing a family tree that illustrates the relationships between individuals and their phenotypes. This analysis helps identify carriers of genetic traits and assess the likelihood of traits being passed on, which is essential for calculating inbreeding coefficients.

Identical By Descent (IBD)

Identical by descent (IBD) refers to alleles that are inherited from a common ancestor without any intervening mutations. In the context of inbreeding, IBD alleles increase the likelihood of homozygosity for certain traits, which can have significant implications for genetic health. Understanding IBD is crucial for calculating the inbreeding coefficient and assessing the genetic risks associated with inbreeding.