Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
2. Mendel's Laws of Inheritance
Pedigrees
Problem 15a
Textbook Question
Consider this human pedigree for a vision defect.
What is the most probable mode of inheritance of the disease? Identify any discrepancies between the pedigree and your proposed mode of transmission, and provide possible explanations for these exceptions.
![Human pedigree chart illustrating a vision defect inheritance pattern.](https://lightcat-files.s3.amazonaws.com/problem_images/c6e26c5f2927e758-1678988291373.jpg)
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1
Examine the pedigree chart to identify affected and unaffected individuals. Affected individuals are typically shaded, while unaffected individuals are not.
Determine if the trait is more common in one sex. If the trait appears predominantly in males, consider X-linked recessive inheritance.
Check if the trait skips generations. If it does, this might suggest a recessive mode of inheritance.
Look for any affected individuals with unaffected parents. This could indicate an autosomal recessive trait, where both parents are carriers.
Identify any discrepancies, such as affected females in an X-linked recessive pattern, and consider possible explanations like new mutations or incorrect pedigree information.
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