Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
12. Gene Regulation in Prokaryotes
Lac Operon
2:35 minutes
Problem 22b
Textbook Question
Textbook QuestionSuppose the lac operon partial diploid cap⁻ I⁺ P⁺ O⁺ Z⁻ Y⁺/ cap⁺ I⁻ P⁺ O⁺ Z⁺ Y⁻ is grown.
Is transcription of -galactosidase and permease inducible, constitutive, or noninducible?
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Lac Operon Structure
The lac operon is a set of genes in E. coli that are involved in the metabolism of lactose. It consists of structural genes (Z, Y, A) and regulatory elements (promoter P, operator O, and the repressor gene I). Understanding the operon's structure is crucial for determining how gene expression is regulated in response to lactose availability.
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Lac Operon Overview
Inducible vs. Constitutive Expression
Inducible expression refers to genes that are turned on in response to specific signals, such as the presence of lactose in the case of the lac operon. In contrast, constitutive expression describes genes that are continuously active regardless of environmental conditions. Recognizing these terms helps in analyzing how the lac operon responds to different genetic configurations.
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Penetrance and Expressivity
Partial Diploidy
Partial diploidy occurs when an organism has two copies of some genes but not others, often due to genetic manipulation. In the context of the lac operon, this can affect the expression of genes like Z and Y, leading to different phenotypic outcomes. Understanding partial diploidy is essential for predicting how mutations and gene interactions influence operon function.
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