Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
13. Gene Regulation in Eukaryotes
Epigenetics, Chromatin Modifications, and Regulation
2:56 minutes
Problem 13a
Textbook Question
Textbook QuestionDefine epigenetics, and provide examples illustrating your definition.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Epigenetics
Epigenetics is the study of heritable changes in gene expression that do not involve alterations to the underlying DNA sequence. These changes can be influenced by various factors, including environmental conditions, lifestyle, and developmental stages. Epigenetic modifications, such as DNA methylation and histone modification, can activate or silence genes, thereby affecting how cells read the genes.
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Chromatin
DNA Methylation
DNA methylation is a key epigenetic mechanism that involves the addition of a methyl group to the DNA molecule, typically at cytosine bases. This modification can inhibit gene expression by preventing the binding of transcription factors or recruiting proteins that compact the DNA, making it less accessible for transcription. For example, increased methylation of tumor suppressor genes can lead to their silencing in cancer cells.
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DNA Proofreading
Histone Modification
Histone modification refers to the chemical alterations of histone proteins around which DNA is wrapped. These modifications, such as acetylation and phosphorylation, can influence the structure of chromatin and, consequently, gene accessibility. For instance, acetylation of histones generally leads to a more relaxed chromatin structure, promoting gene expression, while deacetylation can result in tighter packing and reduced transcription.
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Histone Protein Modifications