The most common reason a physician might recommend that ...

Question

The most common reason a physician might recommend that a woman have maternal serum screening and a karyotype analysis is concern that her fetus may have Down syndrome. Go to the OMIM website at www.ncbi.nlm.nih.gov/omim and look up Down syndrome (OMIM 190685).

How might those genes lead to the main symptoms of Down syndrome?

Accepted Answer

Hello, everyone and welcome to today's video. So Down's Syndrome is caused by the presence of an extra copy of chromosome 21. The extra genetic material needs to be over expression of certain genes which can result in the characteristic features of Down Syndrome. So which gene is over expressed when there is a build up of the beta amyloid protein, which is associated with the development of Alzheimer's disease. Let's analyze each of our answer choices so that we can determine the effect of over expressing each of these genes. Now, as answer choice A we have DS O D one gene, well as it turns out this super oxide, these mutate one, the overexpression of this gene can lead to certain oxidative stress and damage to cells. Now, this is not really what the question is asking for is not related to this beta amyloid protein. So we're going to cancel this out as answer choice B we have the D Y R K one A gene. Now, this gene is going to be related to the or its overexpression is going to be linked to certain intellectual disabilities and certain developmental delays. However, this is not going to be related to this beta amyloid protein. So we're going to cancel this out as answer choice D we have the DS C AM gene. Now, this gene over expression of it is going to affect neural development and is in a way related to certain cognitive deficits in Down syndrome. But again, this is not related to the beta amyloid protein. So we're going to cancel this out and then we have C which is A P P, this is the amyloid precursor protein. So we can already see that it is in fact related to this amyloid protein. Now, over expression to these genes leads to their build up of this beta amyloid protein, which is associated with the development of Alzheimer's disease, which is what the question is asking us for. Therefore, answer choice C A P P is going to be the correct answer to your question. I really hope this video helped you and I hope to see you on the next one.

My Courses

Chemistry

Biology

Math

Physics

Business

Social Sciences

Programming

Product & Marketing