Table of contents

1. Introduction to Genetics51m
2. Mendel's Laws of Inheritance3h 37m
3. Extensions to Mendelian Inheritance2h 41m
4. Genetic Mapping and Linkage2h 28m
5. Genetics of Bacteria and Viruses1h 21m
6. Chromosomal Variation1h 48m
7. DNA and Chromosome Structure56m
8. DNA Replication1h 10m
9. Mitosis and Meiosis1h 34m
10. Transcription1h 0m
11. Translation58m
12. Gene Regulation in Prokaryotes1h 19m
13. Gene Regulation in Eukaryotes44m
14. Genetic Control of Development44m
15. Genomes and Genomics1h 50m
16. Transposable Elements47m
17. Mutation, Repair, and Recombination1h 6m
18. Molecular Genetic Tools19m
- Genetic Cloning
  9m
- Methods for Analyzing DNA
  9m
19. Cancer Genetics29m
- Overview of Cancer
  21m
- Cancer Mutations
  7m
20. Quantitative Genetics1h 26m
21. Population Genetics50m
- Hardy Weinberg
  19m
- Allelic Frequency Changes
  31m
22. Evolutionary Genetics29m

19. Cancer Genetics

Overview of Cancer

Genetics

19. Cancer Genetics

Overview of Cancer

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2:09 minutes

Problem 11

Textbook Question

Go to the website http://www.ncbi.nlm.nih.gov/omim and enter 'Lynch syndrome' in the Search box at the top of the page. From the list of options given, select '#120435—Lynch Syndrome.' Use the information you retrieve to answer the following questions.Provide a brief summary of the normal functions of the protein products of these genes.

Verified step by step guidance

Navigate to the OMIM website at http://www.ncbi.nlm.nih.gov/omim.

Enter 'Lynch syndrome' in the search box and press enter.

From the search results, select the entry labeled '#120435—Lynch Syndrome.'

Review the information provided in the entry, focusing on the sections that describe the genes associated with Lynch syndrome.

Summarize the normal functions of the protein products of these genes, which typically involve DNA mismatch repair.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Lynch Syndrome

Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is a genetic condition that increases the risk of various cancers, particularly colorectal and endometrial cancers. It is caused by mutations in mismatch repair (MMR) genes, which are responsible for correcting DNA replication errors. Understanding Lynch syndrome is crucial for recognizing the implications of gene mutations on cancer risk and the importance of genetic testing.

Mismatch Repair Genes

Mismatch repair (MMR) genes, including MLH1, MSH2, MSH6, and PMS2, play a vital role in maintaining genomic stability by repairing errors that occur during DNA replication. When these genes are mutated, the efficiency of DNA repair is compromised, leading to an accumulation of mutations that can result in cancer. Knowledge of these genes is essential for understanding the molecular basis of Lynch syndrome and its associated cancer risks.

Protein Function

The protein products of MMR genes are enzymes that facilitate the recognition and repair of mismatched DNA bases. These proteins work together in a complex pathway to ensure accurate DNA replication and prevent mutations from being passed on during cell division. A summary of their normal functions highlights how disruptions in these proteins contribute to the development of Lynch syndrome and its related cancers.