Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
18. Molecular Genetic Tools
Methods for Analyzing DNA
1:49 minutes
Problem 2
Textbook Question
Textbook QuestionCompare and contrast the terms Paternity Index (PI) and Combined Paternity Index (CPI). How does each contribute to paternity determination?
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Paternity Index (PI)
The Paternity Index (PI) is a statistical measure used in paternity testing that compares the likelihood of a genetic profile being present in a child if the alleged father is the biological parent versus if he is not. A PI greater than 1 indicates that the evidence supports the alleged father being the biological parent, while a PI less than 1 suggests the opposite. It is calculated for each genetic marker tested.
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Combined Paternity Index (CPI)
The Combined Paternity Index (CPI) is an extension of the Paternity Index that integrates the PIs from multiple genetic markers to provide a more comprehensive assessment of paternity. The CPI is calculated by multiplying the PIs of all the markers tested, resulting in a single value that reflects the overall strength of the evidence. A higher CPI indicates a stronger likelihood of paternity.
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Paternity Determination
Paternity determination involves using genetic testing to establish whether a man is the biological father of a child. This process typically relies on analyzing specific genetic markers, such as short tandem repeats (STRs), to compare the DNA of the child, the alleged father, and sometimes the mother. The results, expressed through PI and CPI, help quantify the probability of paternity, aiding legal and personal decisions.
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