Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
3. Extensions to Mendelian Inheritance
Epistasis and Complementation
5:41 minutes
Problem 21a
Textbook Question
Textbook QuestionA male and a female mouse are each from pure-breeding albino strains. They have a litter of 10 pups, all of which have normal pigmentation. The F₁ pups are crossed to one another to produce 56 F₂ mice, of which 31 are normally pigmented and 25 are albino.
What genetic phenomenon explains the F₂ results? Use your allelic symbols to explain the F₂ results.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Mendelian Inheritance
Mendelian inheritance refers to the principles of heredity established by Gregor Mendel, which include the concepts of dominant and recessive alleles. In this case, the normal pigmentation allele is dominant over the albino allele. When two pure-breeding albino mice (homozygous recessive) are crossed, all offspring (F₁) inherit the dominant normal pigmentation allele from one parent, resulting in normal pigmentation.
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Punnett Square
A Punnett square is a diagram used to predict the genotypes of offspring from a genetic cross. In this scenario, the F₁ generation (heterozygous for normal pigmentation) is crossed, leading to a 1:2:1 ratio of genotypes in the F₂ generation. This results in the expected phenotypic ratio of 3 normal pigmentation to 1 albino, which aligns with the observed 31 normally pigmented and 25 albino mice.
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Allelic Symbols
Allelic symbols are shorthand notations used to represent different alleles of a gene. In this case, we can denote the normal pigmentation allele as 'N' (dominant) and the albino allele as 'n' (recessive). The F₁ generation would be 'Nn', and when crossed, the F₂ generation would exhibit the genotypes NN, Nn, and nn, leading to the observed phenotypic ratios.
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