Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
6. Chromosomal Variation
Chromosomal Mutations: Aneuploidy
1:15 minutes
Problem 16
Textbook Question
Indicate the expected number of Barr bodies in interphase cells of individuals with Klinefelter syndrome; Turner syndrome; and karyotypes 47,XYY, 47,XXX, and 48,XXXX.
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1
Understand that a Barr body is an inactivated X chromosome in a cell with more than one X chromosome.
Recall that the number of Barr bodies is calculated as the total number of X chromosomes minus one.
For Klinefelter syndrome (47,XXY), calculate the number of Barr bodies by subtracting one from the number of X chromosomes.
For Turner syndrome (45,X), note that there is only one X chromosome, so calculate the number of Barr bodies accordingly.
Apply the same calculation method for karyotypes 47,XYY, 47,XXX, and 48,XXXX, considering the number of X chromosomes in each case.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Barr Bodies
Barr bodies are inactivated X chromosomes found in the cells of individuals with more than one X chromosome. In females, typically one X chromosome is active while the others are condensed into Barr bodies. This process is crucial for dosage compensation, ensuring that gene expression levels are balanced between males and females.
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Other Chromatin Modifications
Klinefelter Syndrome
Klinefelter syndrome is a genetic condition in males characterized by the presence of an extra X chromosome, resulting in a karyotype of 47,XXY. Individuals with this syndrome typically have one Barr body in their interphase cells, as one X chromosome is inactivated while the other remains active.
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Human Sex Chromosomes
Turner Syndrome
Turner syndrome occurs in females who have only one X chromosome, resulting in a karyotype of 45,X. Since there is only one X chromosome present, there are no Barr bodies in interphase cells, as there are no additional X chromosomes to inactivate.
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