Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
12. Gene Regulation in Prokaryotes
Lac Operon
2:15 minutes
Problem 22a
Textbook Question
Textbook QuestionSuppose the lac operon partial diploid cap⁻ I⁺ P⁺ O⁺ Z⁻ Y⁺/ cap⁺ I⁻ P⁺ O⁺ Z⁺ Y⁻ is grown.
Explain how genetic complementation contributes to the growth habit of this strain.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Lac Operon
The lac operon is a set of genes in E. coli that are involved in the metabolism of lactose. It consists of structural genes (Z, Y, A) and regulatory elements (promoter P, operator O). The operon is controlled by the presence or absence of lactose, which influences the expression of these genes, allowing the bacteria to utilize lactose as an energy source.
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Lac Operon Overview
Genetic Complementation
Genetic complementation occurs when two different genetic mutations in a diploid organism can restore a normal phenotype when present together. In the context of the lac operon, if one allele produces a functional protein while the other does not, the functional protein can compensate for the defective one, allowing the organism to grow under conditions where it would otherwise be unable to.
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Complementation
Partial Diploidy
Partial diploidy refers to a genetic condition where an organism has two copies of some genes but only one copy of others. In the case of the lac operon, the presence of both cap and I genes in different states (mutant and wild-type) allows for the study of gene interactions and complementation, providing insights into how these genes regulate lactose metabolism in bacteria.
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