Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
3. Extensions to Mendelian Inheritance
Organelle DNA
2:28 minutes
Problem 20b
Textbook Question
Textbook QuestionPayne, B. A. et al. (2013) present evidence that a low level of heteroplasmic mtDNA exists in all tested healthy individuals.
What are two likely sources of such heteroplasmy?
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Mitochondrial DNA (mtDNA)
Mitochondrial DNA (mtDNA) is the genetic material found in mitochondria, the energy-producing organelles in cells. Unlike nuclear DNA, mtDNA is inherited maternally and is present in multiple copies within each mitochondrion. Variations in mtDNA can lead to heteroplasmy, where different mtDNA sequences coexist within an individual, influencing cellular function and health.
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Heteroplasmy
Heteroplasmy refers to the presence of more than one type of mitochondrial DNA within a single cell or individual. This condition can arise from mutations in mtDNA or from the mixing of mtDNA from different maternal lineages. Heteroplasmy can affect the expression of mitochondrial diseases and is a key factor in understanding mitochondrial genetics and inheritance patterns.
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Sources of Heteroplasmy
Heteroplasmy can originate from several sources, including mutations that occur during DNA replication or damage from environmental factors, leading to a mix of normal and mutated mtDNA. Additionally, the maternal inheritance of mtDNA can introduce variations, as different eggs may carry distinct mtDNA populations. These sources contribute to the genetic diversity observed in healthy individuals.
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