Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
3. Extensions to Mendelian Inheritance
Epistasis and Complementation
4:43 minutes
Problem 21b
Textbook Question
Textbook QuestionA male and a female mouse are each from pure-breeding albino strains. They have a litter of 10 pups, all of which have normal pigmentation. The F₁ pups are crossed to one another to produce 56 F₂ mice, of which 31 are normally pigmented and 25 are albino.
Using clearly defined allele symbols of your own choosing, give the genotypes of parental and F₁ mice. What genetic phenomenon explains these parental and F₁ phenotypes?
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Mendelian Inheritance
Mendelian inheritance refers to the principles of heredity established by Gregor Mendel, which include the concepts of dominant and recessive alleles. In this scenario, the albino trait is likely recessive, while normal pigmentation is dominant. This means that the albino mice must have two copies of the recessive allele, while the normal pigmentation can be present in either homozygous dominant or heterozygous forms.
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Genotype and Phenotype
The genotype is the genetic makeup of an organism, represented by the alleles it carries, while the phenotype is the observable physical or biochemical characteristics resulting from the genotype. In this case, the parental mice are homozygous for the albino allele (aa), and the F₁ generation, being heterozygous (Aa), exhibits the dominant phenotype of normal pigmentation.
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Punnett Square
A Punnett square is a diagram used to predict the genotypes and phenotypes of offspring from a genetic cross. By using a Punnett square for the F₁ generation (Aa x Aa), we can visualize the expected ratios of the offspring's genotypes, which explains the observed 31 normally pigmented and 25 albino F₂ mice, consistent with a 3:1 phenotypic ratio typical of a monohybrid cross.
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