The frequencies of the four alleles contributed to the child by possible father F1 in Problem 7 are 0.18, 0.23, 0.13, and 0.14. Calculate the Combined Paternity Index (CPI) for the four genes in this analysis.

Key Concepts

Allele Frequency

Allele frequency refers to how often a particular allele appears in a population compared to other alleles for the same gene. It is expressed as a proportion or percentage and is crucial for understanding genetic diversity and inheritance patterns. In this context, the frequencies of the four alleles provided by the father F1 are essential for calculating the Combined Paternity Index.

Combined Paternity Index (CPI)

The Combined Paternity Index (CPI) is a statistical measure used in genetics to evaluate the likelihood of paternity based on the allele frequencies of multiple genes. It combines the probabilities of observing the child's alleles given the father's alleles, providing a comprehensive assessment of paternity. A higher CPI indicates a stronger likelihood that the tested individual is the biological father.

Genetic Contribution

Genetic contribution refers to the genetic material passed from parents to offspring, which influences the offspring's traits. In the context of paternity testing, understanding how each parent's alleles contribute to the child's genotype is vital for calculating probabilities and indices like the CPI. This concept underscores the importance of allele combinations in determining familial relationships.