Neurofibromatosis 1 (NF1) is an autosomal dominant disor...

Question

Neurofibromatosis 1 (NF1) is an autosomal dominant disorder inherited on human chromosome 17. Part of the analysis mapping the NF1 gene to chromosome 17 came from genetic linkage studies testing segregation of NF1 and DNA genetic markers on various chromosomes. A DNA marker with two alleles, designated 1 and 2, is linked to NF1. The pedigree below shows segregation of NF1 (darkened symbols) and gives genotypes for the DNA marker for each family member.

Based on the phase of alleles on chromosomes in generation II, is there any evidence of recombination among the eight offspring in generation III? Explain. <>

Accepted Answer

Welcome back, everyone. Here's our next question. It says Blank is a genetic approach that looks across families for chromosomal segments that cos segregate with the disease phenotype. And our answer choices are a linkage analysis. B PC R analysis C gene sequencing and D northern blotting. Well, by looking for chromosomal segregate segments that cos segregate with disease phenotype. That means you have a genetic disease where its location is unknown location, mean the location of the gene. So where exactly it is on the chromosome is not known. So to look for that, you look for chromosomal segments of known location. So traits whose physical location on the chromosome is known and you say which are inherited with the disease. So you say people that are affected by the disease always seem to inherit this trait at the same time. And this technique is called linkage analysis, which is our choice. A here, let's look at our other answer choices to understand why they're not correct choice. B is PC R analysis. Well, PC R is used to generate a large number of copies of a specific DNA segment, but that's not what we have here where we're specifically looking for the physical location of a gene on a chromosome. So that's why that's not correct to ac gene sequencing. Um That of course, is finding the technique that allows you to find the base pair sequence of a specific gene. So we're not just looking for base pairs here, we're looking for where on the chromosome is this gene located. So that's why Tracy is not correct. And finally, Northern bo is a technique of using labeled the DNA probes to identify R N A sequences of interest but not what we're looking for. So it's choice D is not our answer. So again, choice, a linkage analysis is a genetic approach that looks across families for chromosomal segments that cos segregate with a disease phenotype. See you in the next video.

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