It has been shown that infectious agents such as viruses often exert a dramatic effect on their host cell's genome architecture. In many cases, viruses induce methylation of host DNA sequences in order to enhance their infectivity. What specific host gene functions would you consider as strong candidates for such methylation by infecting viruses?

Key Concepts

DNA Methylation

DNA methylation is a biochemical process involving the addition of a methyl group to the DNA molecule, typically at cytosine bases. This modification can regulate gene expression by silencing genes, thereby influencing various cellular functions. In the context of viral infections, viruses may induce methylation to manipulate host gene expression to favor their replication and survival.

Viral Manipulation of Host Genomes

Viruses can interact with host cellular machinery to alter the host genome, often to create a more favorable environment for their replication. This manipulation can include changes in gene expression, chromatin structure, and even the introduction of viral genes into the host genome. Understanding which host genes are targeted can provide insights into viral strategies and host defenses.

Candidate Genes for Methylation

Candidate genes for methylation during viral infection are typically those involved in immune response, cell cycle regulation, and apoptosis. These genes are crucial for maintaining cellular homeostasis and defense against pathogens. By targeting these genes, viruses can evade immune detection and promote their own replication, making them prime candidates for studying the effects of viral-induced methylation.