Bacterial conjugation, mediated mainly by conjugative plasmids su...

Question

Bacterial conjugation, mediated mainly by conjugative plasmids such as F, represents a potential health threat through the sharing of genes for pathogenicity or antibiotic resistance. Given that more than 400 different species of bacteria coinhabit a healthy human gut and more than 200 coinhabit human skin, Francisco Dionisio [(2002) Genetics 162:1525–1532] investigated the ability of plasmids to undergo between-species conjugal transfer. The following data are presented for various species of the enterobacterial genus Escherichia. The data are presented as 'log base 10' values; for example, -2.0 would be equivalent to 10⁻² as a rate of transfer. Assume that all differences between values presented are statistically significant.

Donor _
Recipient E. chrysanthemi E. blattae E. fergusonii E. coli
E. chrysanthemi -2.4 -4.7 -5.8 -3.7
E. blattae -2.0 -3.4 -5.2 -3.4 
E. fergusonii -3.4 -5.0 -5.8 -4.2
E. coli -1.7 -3.7 -5.3 -3.5

What is the significance of these findings in terms of human health?

Accepted Answer

Hello everyone and welcome to today's video. So when it comes to the conjugation of the age F. R. Bacterium and an F minus bacterium which of the following statements is not true. Remember that we're looking for the incorrect statement. Um on or answer choices but remember that conjugation is one of the methods of horizontal gene transfer. So keep that in mind as we solve this problem. Let's begin by looking at answer choice. A. The D. N. A. Of the main chromosome is transferred to a recipient cell during an A H. F. R. An F minus conjugation. Well this is actually going to be a correct statement because in this type of conjugation this H. F. R. Is going to be donating this F. Plasmid to the F. Negative bacterium. Because of this we're going to cancel this out because remember that we're looking for the incorrect statement. Moving on we have during conjugation the H. F. R. And D. F minus bacteria established a physical connection recall from previous videos that there is going to be this physical connection called the pilots during conjugation. That is going to allow gene transfer between two bacteria. This is a correct statement. So we're going to cancel it as well that we have C. Genes from the H. F. R. Bacterium that is close to the leading side of the f origin of transfer are more likely to be transferred to the F minus bacteria than genes from the F minus bacteria that are further away. We'll remember that here we have an origin of transfer which is when we're transfer is going to begin now. What this statement is saying is that genes closer to the origin of transfer are more likely to be transferred between the two bacterium. And this is a correct statement as well. So we're going to cancel it out. Then we have the asked the H. F. R chromosome replicates. The free three prime end moves through the transfer portal that connects the two bacteria. This is going to be our incorrect statement. But why? Well it is not the three prime end that is going to move through the transfer portal is going to be the five prime end that first enters this trance report. Because of this. We're going to be highlighting answer choice D as the final answer to our question and the incorrect statement and modern answer choices. I really hope this video helped you and I hope to see you on the next one.

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