Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
17. Mutation, Repair, and Recombination
Induced Mutations
7:10 minutes
Problem 34a
Textbook Question
Textbook QuestionUsing your knowledge of DNA repair pathways, choose the pathway that would be used to repair the following types of DNA damage. Explain your reasoning.
a cytosine that has been deaminated to uracil
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
DNA Repair Mechanisms
DNA repair mechanisms are cellular processes that correct damage to the DNA molecule. These mechanisms are crucial for maintaining genomic integrity and preventing mutations that could lead to diseases such as cancer. Different types of DNA damage require specific repair pathways, including base excision repair, nucleotide excision repair, and mismatch repair.
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Repair Pathways
Base Excision Repair (BER)
Base excision repair (BER) is a DNA repair pathway that specifically addresses small, non-helix-distorting base lesions, such as deaminated bases. In this process, DNA glycosylases recognize and remove the damaged base, creating an abasic site. Subsequently, other enzymes fill in the gap with the correct nucleotide, restoring the DNA sequence.
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Repair Pathways
Deamination of Cytosine
Deamination of cytosine is a chemical reaction where an amino group is removed from the cytosine base, converting it into uracil. This alteration can lead to mispairing during DNA replication if not repaired, as uracil pairs with adenine instead of guanine. The presence of uracil in DNA is a signal for the base excision repair pathway to initiate repair.
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Base Distortions
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