In Section 21.10 we briefly discussed the Human Proteome Map (HPM). An interactive Web site for the HPM is available at http://www.humanproteomemap.org. Visit this site, and then answer the questions in parts (a) and (b) and complete part (c). Use the 'Query' tab and select the 'Gene family' dropdown menu to do a search on the distribution of proteins encoded by a pathway of interest to you. Search in fetal tissues, adult tissues, or both.

Key Concepts

Human Proteome Map (HPM)

The Human Proteome Map (HPM) is a comprehensive resource that catalogs the proteins expressed in human tissues and their functions. It provides insights into the distribution and abundance of proteins across different tissues, which is crucial for understanding biological processes and disease mechanisms. The HPM serves as a valuable tool for researchers to explore protein expression patterns and their implications in health and disease.

Gene Family

A gene family is a group of related genes that share a common ancestor and typically have similar functions. Members of a gene family often encode proteins that perform related roles in biological pathways. Understanding gene families is essential for studying the evolution of genes and their functional diversity, as well as for investigating how different proteins interact within specific pathways.

Tissue-Specific Protein Expression

Tissue-specific protein expression refers to the phenomenon where certain proteins are produced in specific tissues at varying levels. This concept is vital for understanding how proteins contribute to the unique functions of different tissues, such as fetal versus adult tissues. Analyzing tissue-specific expression helps researchers identify potential biomarkers for diseases and understand developmental processes.