Mutations in mitochondrial DNA appear to be responsible ...

Question

Mutations in mitochondrial DNA appear to be responsible for a number of neurological disorders, including myoclonic epilepsy and ragged-red fiber disease, Leber's hereditary optic neuropathy, and Kearns-Sayre syndrome. In each case, the disease phenotype is expressed when the ratio of mutant to wild-type mitochondria exceeds a threshold peculiar to each disease, but usually in the 60 to 95 percent range.

Given that these are debilitating conditions, why has no cure been developed? Can you suggest a general approach that might be used to treat, or perhaps even cure, these disorders?

Accepted Answer

Hi everyone. Let's take a look at this practice problem together. Which of the following provides the genetic basis of kieran Sayer syndrome or K. S. S. Now K. S. S is a rare neuro muscular disorder and it primarily in the beginning affects the eyes and the musculature of the eyes. It's caused by mutations in mitochondrial D. N. A. But what is the genetic basis of this? What are those mutations? So let's look at our options. Is it a deletions at different positions of mitochondrial D. N. A. Is it B insertions in some portions of mitochondrial D. N. A? Is it c incorrect base pair matching in some areas of mitochondrial D. N. A. Or D. Duplication of introns in many parts of mitochondrial D. N. A. So our correct answer is A. K. S. S mutations are deletions at different positions of mitochondrial D. N. A. And the amount of deletions can vary. And it's been shown that the more deletions there are. So the greater the number of deletions, the greater the severity of the disease. It is not caused by insertions. It's not caused by mismatched pairing or duplication of introns. So again the correct answer is a Alright everybody. I hope you found this helpful and I'll see you soon for the next practice problem.

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