- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
In humans, hemophilia A (OMIM 306700) is an X-linked recessive disorder that affects the gene for factor VIII protein, which is essential for blood clotting. The dominant and recessive alleles for the factor VIII gene are represented by H and h. Albinism is an autosomal recessive condition that results from mutation of the gene producing tyrosinase, an enzyme in the melanin synthesis pathway. A and a represent the tyrosinase alleles. A healthy woman named Clara (II-2), whose father (I-1) has hemophilia and whose brother (II-1) has albinism, is married to a healthy man named Charles (II-3), whose parents are healthy. Charles's brother (II-5) has hemophilia, and his sister (II-4) has albinism. The pedigree is shown below.
Determine the probability that the first child of Clara and Charles will be a
i. boy with hemophilia
ii. girl with albinism
iii. healthy girl
iv. boy with both albinism and hemophilia
v. boy with albinism
vi. girl with hemophilia <>