Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
4. Genetic Mapping and Linkage
Trihybrid Cross
4:44 minutes
Problem 25b
Textbook Question
Textbook QuestionIn rabbits, chocolate-colored fur (w⁺) is dominant to white fur (w), straight fur (c⁺) is dominant to curly fur (c), and long ear (s⁺) is dominant to short ear (s). The cross of a trihybrid rabbit with straight, chocolate-colored fur and long ears to a rabbit that has white, curly fur and short ears produces the following results:
Phenotype Number
White, short, straight 13
Chocolate, long, straight 165
Chocolate, long, curly 13
White, long, straight 82
Chocolate, short, straight 436
Chocolate, short, curly 79
White, short, curly 162
White, long, curly 450
1400
Calculate the recombination frequencies between each of the adjacent pairs of genes.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Dominance and Alleles
In genetics, dominance refers to the relationship between alleles, where one allele (dominant) masks the expression of another (recessive). In this case, chocolate-colored fur (w⁺) is dominant over white fur (w), meaning that a rabbit with at least one w⁺ allele will exhibit chocolate fur. Understanding dominance is crucial for predicting phenotypes in offspring based on parental genotypes.
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Variations on Dominance
Phenotypic Ratios
Phenotypic ratios represent the relative frequencies of different phenotypes in the offspring resulting from a genetic cross. In the provided data, the phenotypes of the offspring are listed with their respective counts, which can be used to determine the ratios of each phenotype. Analyzing these ratios helps in understanding the inheritance patterns and the effects of dominant and recessive alleles.
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Mutations and Phenotypes
Recombination Frequency
Recombination frequency is a measure of the likelihood that two genes will be separated during meiosis due to crossing over. It is calculated by determining the proportion of recombinant offspring to the total number of offspring. This concept is essential for mapping genes on chromosomes and understanding genetic linkage, which is relevant when analyzing the inheritance of multiple traits, as seen in the rabbit cross.
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Recombination after Single Strand Breaks
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