Table of contents
- 1. Introduction to Genetics51m
- 2. Mendel's Laws of Inheritance3h 37m
- 3. Extensions to Mendelian Inheritance2h 41m
- 4. Genetic Mapping and Linkage2h 28m
- 5. Genetics of Bacteria and Viruses1h 21m
- 6. Chromosomal Variation1h 48m
- 7. DNA and Chromosome Structure56m
- 8. DNA Replication1h 10m
- 9. Mitosis and Meiosis1h 34m
- 10. Transcription1h 0m
- 11. Translation58m
- 12. Gene Regulation in Prokaryotes1h 19m
- 13. Gene Regulation in Eukaryotes44m
- 14. Genetic Control of Development44m
- 15. Genomes and Genomics1h 50m
- 16. Transposable Elements47m
- 17. Mutation, Repair, and Recombination1h 6m
- 18. Molecular Genetic Tools19m
- 19. Cancer Genetics29m
- 20. Quantitative Genetics1h 26m
- 21. Population Genetics50m
- 22. Evolutionary Genetics29m
4. Genetic Mapping and Linkage
Crossing Over and Recombinants
3:27 minutes
Problem 24d
Textbook Question
Textbook QuestionThe boss in your laboratory has just heard of a proposal by another laboratory that genes for eye color and the length of body bristles may be linked in Drosophila. Your lab has numerous pure-breeding stocks of Drosophila that could be used to verify or refute genetic linkage. In Drosophila, red eyes (c⁺) are dominant to brown eyes (c) and long bristles (d⁺) are dominant to short bristles (d). Your lab boss asks you to design an experiment to test the genetic linkage of eye color and bristle-length genes, and to begin by crossing a pure-breeding line homozygous for red eyes and short bristles to a pure-breeding line that has brown eyes and long bristles.
Give the genotypes of the pure-breeding parental flies and the genotype(s) and phenotype(s) of the F₁ progeny they produce.
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Key Concepts
Here are the essential concepts you must grasp in order to answer the question correctly.
Genetic Linkage
Genetic linkage refers to the tendency of genes located close to each other on the same chromosome to be inherited together during meiosis. This phenomenon can affect the expected ratios of offspring phenotypes in genetic crosses. If two traits are linked, the offspring will show a higher frequency of parental combinations of traits than expected under independent assortment.
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Genotype and Phenotype
The genotype is the genetic constitution of an organism, represented by the alleles it carries, while the phenotype is the observable physical or biochemical characteristics resulting from the genotype and environmental influences. In this context, the genotypes of the parental flies will determine the phenotypes of the F₁ progeny, which can be predicted based on the dominance relationships of the alleles involved.
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Drosophila Genetics
Drosophila melanogaster, commonly known as the fruit fly, is a model organism in genetics due to its simple genetic structure, short life cycle, and ease of breeding. In this experiment, the traits of eye color and bristle length are used to illustrate Mendelian inheritance patterns, where dominant and recessive alleles determine the phenotypic outcomes in the offspring of the genetic crosses.
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