17. Mutation, Repair, and Recombination
Induced Mutations
2:02 minutes
Problem 31
Textbook Question
Textbook QuestionExperiments by Charles Yanofsky in the 1950s and 1960s helped characterize the nature of tryptophan synthesis in E. coli. In one of Yanofsky's experiments, he identified glycine (Gly) as the wild-type amino acid in position 211 of tryptophan synthetase, the product of the trpA gene. He identified two independent missense mutants with defective tryptophan synthetase at these positions that resulted from base-pair substitutions. One mutant encoded arginine (Arg) and another encoded glutamic acid (Glu). At position 235, wild-type tryptophan synthetase contains serine (Ser) but a base-pair substitution mutant encodes leucine (Leu). At position 243, the wild-type polypeptide contains glutamine and a base-pair substitution mutant encodes a stop codon. Identify the most likely wild-type codons for positions 211, 235, and 243. Justify your answer in each case.
Verified Solution
This video solution was recommended by our tutors as helpful for the problem above
Video duration:
2mPlay a video:
356
views
Was this helpful?
Related Videos
Related Practice