19. Chemical Thermodynamics
Gibbs Free Energy And Equilibrium
4PRACTICE PROBLEM
Chromium (III) picolinate, [CrPic3], is a supplement used to treat type II diabetes. It is a source of Cr3+ ions that are shown to increase insulin sensitivity. Even though [Cr(Pic3)] is more efficiently absorbed in the GI tract, its absorption is still quite low. It might be expected that the absorption of Cr3+ will be higher in the stomach because of the following reaction:
[CrPic3](aq) + 3 H3O+(aq) ⇌ Cr3+(aq) + 3 HPic(aq) + 6 H2O(l)
Explain the low absorption of [CrPic3] by predicting the spontaneity of the reaction under standard conditions. (For [Cr(Pic3)], Kf = 3.548×104; for picolinic acid (HPic), Ka = 0.1023)
Chromium (III) picolinate, [CrPic3], is a supplement used to treat type II diabetes. It is a source of Cr3+ ions that are shown to increase insulin sensitivity. Even though [Cr(Pic3)] is more efficiently absorbed in the GI tract, its absorption is still quite low. It might be expected that the absorption of Cr3+ will be higher in the stomach because of the following reaction:
[CrPic3](aq) + 3 H3O+(aq) ⇌ Cr3+(aq) + 3 HPic(aq) + 6 H2O(l)
Explain the low absorption of [CrPic3] by predicting the spontaneity of the reaction under standard conditions. (For [Cr(Pic3)], Kf = 3.548×104; for picolinic acid (HPic), Ka = 0.1023)