Explain what qualifies the gene therapy method to cure sickle cell disease as an ex vivo approach.



Describe why biologists often generate genetically modified organisms (GMOs) for research purposes.

Key Concepts
Genetic Modification
Research Applications
Ethical Considerations
After finding a gene that causes a disease, researchers often introduce the defective allele into mice to create an animal model of the disease. Why are these models valuable? a. They allow the testing of potential drug therapies without endangering human patients. b. They allow the sequencing of the mutant allele. c. They allow the production of large quantities of the defective gene product, usually a protein. d. They allow the study of how the gene was transmitted from parents to offspring.
A friend who works in a research lab performed a GWAS and discovered a tight association between a SNP allele and the disease she is studying. She concluded that the SNP allele must be the mutation that causes the disease. Explain why she is likely to be wrong.