A friend is interested in isolating genes that are expressed solely in liver cells but only has access to skin cells. She asks you for advice on whether to start her studies. What will you say?

Verified step by step guidance

1. Explain that genes expressed in liver cells may not be expressed in skin cells due to the specific functions and environments of each cell type.
2. Suggest considering alternative methods to access liver cell gene expression data, such as using public databases or collaborating with a lab that has liver cell samples.
3. Discuss the possibility of using techniques like RT-PCR or microarray analysis on liver cells to identify genes specifically expressed in those cells.
4. Advise on the importance of confirming the liver-specific expression of these genes through additional experiments, such as in situ hybridization or immunohistochemistry on liver tissue.
5. Recommend reviewing scientific literature to find previously identified liver-specific genes as a starting point for her research.