Antibiotic resistance is becoming common among organisms that cause a variety of human diseases. All of the following strategies help reduce the risk of antibiotic resistance evolving in a susceptible bacterial population except                  . a. using antibiotics only when appropriate, for bacterial infections that are not clearing up naturally; b. using the drugs as directed, taking all the antibiotic over the course of days prescribed; c. using more than one antibiotic at a time for difficult-to-treat organisms; d. preventing natural selection by reducing the amount of evolution the organisms can perform; e. reducing the use of antibiotics in non–health-care settings, such as agriculture

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1. Identify the strategies listed in the problem that are known to help reduce antibiotic resistance. These include using antibiotics only when necessary, following the prescribed course of antibiotics, and reducing the use of antibiotics in non-healthcare settings.
2. Analyze the option that suggests using more than one antibiotic at a time for difficult-to-treat organisms. Consider how this practice might affect bacterial populations and the development of resistance.
3. Evaluate the option that mentions preventing natural selection by reducing the amount of evolution the organisms can perform. Reflect on the feasibility and scientific basis of this strategy in the context of bacterial evolution and antibiotic resistance.
4. Compare all the options to determine which one is least likely to help reduce the risk of antibiotic resistance based on current scientific understanding of how resistance develops and spreads among bacterial populations.
5. Conclude which strategy does not align with the effective measures for controlling antibiotic resistance, considering the mechanisms of bacterial adaptation and survival against antibiotic pressures.