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Ch. 19 Blood
Chapter 19, Problem 19.b

Predict how abnormal hemoglobin proteins that contain only two iron ions, instead of four, would affect homeostasis.

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Understand the role of hemoglobin: Hemoglobin is a protein in red blood cells responsible for transporting oxygen from the lungs to the rest of the body and returning carbon dioxide from the body to the lungs.
Recognize the structure of normal hemoglobin: Normal hemoglobin contains four iron ions, each bound to a heme group, allowing it to bind up to four oxygen molecules.
Consider the impact of having only two iron ions: With only two iron ions, the hemoglobin would have a reduced capacity to bind oxygen, potentially carrying only half the amount of oxygen compared to normal hemoglobin.
Analyze the effect on oxygen transport: Reduced oxygen-carrying capacity would lead to decreased oxygen delivery to tissues, potentially causing symptoms of hypoxia, such as fatigue and shortness of breath.
Evaluate the impact on homeostasis: The body's homeostatic mechanisms, such as increased heart rate and respiratory rate, might be activated to compensate for the reduced oxygen delivery, but chronic compensation could lead to further physiological stress.

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Key Concepts

Here are the essential concepts you must grasp in order to answer the question correctly.

Hemoglobin Structure and Function

Hemoglobin is a protein in red blood cells responsible for transporting oxygen from the lungs to the tissues and returning carbon dioxide to the lungs. It typically contains four iron ions, each capable of binding one oxygen molecule. If hemoglobin contains only two iron ions, its ability to bind and transport oxygen would be significantly impaired, leading to reduced oxygen delivery to tissues.
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Homeostasis

Homeostasis refers to the body's ability to maintain stable internal conditions despite external changes. This includes regulating temperature, pH, and the concentration of various substances, including oxygen. Disruption in oxygen transport due to abnormal hemoglobin can lead to hypoxia, triggering compensatory mechanisms that may strain other systems, such as increased heart rate or respiratory rate.
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Oxygen Saturation and Delivery

Oxygen saturation is the measure of how much oxygen the blood is carrying as a percentage of the maximum it could carry. Abnormal hemoglobin with fewer iron ions would lead to lower oxygen saturation levels, meaning less oxygen is available for cellular metabolism. This can result in fatigue, organ dysfunction, and other symptoms associated with inadequate oxygen supply, further challenging the body's homeostatic balance.
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