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Ch. 11 Introduction to the Nervous System and Nervous Tissue
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All textbooksErin C. Amerman 2nd EditionCh. 11 Introduction to the Nervous System and Nervous TissueProblem 11.3a

Chapter 11, Problem 11.3a

Albert accidentally ingests the poison tetrodotoxin from the pufferfish, which you know blocks voltage-gated Na+ channels. Predict the symptoms Albert will experience from this poisoning.

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Hey, everyone. Let's take a look at this question together. Andrea went on a trip to Japan and wanted to try the famous UGU which is a Japanese puffer fish. And after eating at a random restaurant, Andrea was found paralyzed in her hotel room. What is the toxin that is found in most puffer fish? Is it answer choice. A tetrodotoxin. Answer choice. B phytotoxin. Answer choice C mycotoxin or answer choice. D none of the above. Let's work this problem out together to try to figure out which of the following answer choices is the correct toxin that is found in most puffer fish. Don't. In order to solve this question, we have to recall what toxin is found in most puffer fish to determine what toxin resulted in Andrea being paralyzed. And we know that toxin that is found in most puffer fish is called tetrodotoxin, which tetrodotoxin interferes with the signals from the nerves to the muscles by blocking the sodium channels, which results in rapid weakening and paralysis of muscles, including muscles in the respiratory tract, which can lead to respiratory arrest as well as death. So looking at our answer choices, we can identify answer choice. A which is tetrodotoxin, the correct answer and all other answer choices are incorrect. I hope you found this video to be helpful. Thank you and goodbye.
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Mark the following statements as true or false. If a statement if false, correct it to make a true statement.


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Albert, the patient in question 3, takes the drug lithium, which reduces the permeability of the neuronal axolemma to Na+ (that is, it allows fewer Na+ to enter the axon). Predict the effect this would normally have on his neuronal action potentials. Do you think this drug would be beneficial or harmful, considering his condition?

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P​​redict the effect that tetrodotoxin would have on Albert's muscle fiber action potentials (see question 3). Would it affect end-plate potentials at the motor end plate? Why or why not? (Connects to Chapter 10)

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