Chemically gated channels open in response to changes in membrane potential, while voltage-gated channels open when specific chemicals bind to them.

Chemically gated channels respond to physical distortion of the membrane, while voltage-gated channels open or close in response to changes in membrane potential.

Chemically gated channels open or close when they bind specific chemicals, while voltage-gated channels open or close in response to changes in membrane potential.

Chemically gated channels are abundant in sensory receptors, while voltage-gated channels are characteristic of excitable cell membranes.