Which of the following accurately characterizes our current understanding of cancer development?
A
Mutations in a single gene cannot significantly increase susceptibility to cancer.
B
Study results suggest that mutations in genes that are transcribed into ncRNA do not likely contribute to cancer development.
C
We now understand that all cancers result from some mutation in the p53 gene.
D
Nearly all cancers are caused by the multistep accumulation of mutations over the life span of the individual.
E
In order for a cell to become fully cancerous, it typically must have at least one active oncogene and the mutation or loss of several tumor-suppressor genes.