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Pemphigus Vulgaris
Pemphigus vulgaris is an autoimmune disorder characterized by the formation of blisters on the skin and mucous membranes. The immune system mistakenly targets desmosomes, which are structures that help cells adhere to one another, leading to the separation of skin layers and the development of painful lesions.
Desmosomes
Desmosomes are specialized cell structures that provide adhesion between epithelial cells, maintaining the integrity of tissues. They are crucial for skin stability, and their disruption in pemphigus vulgaris results in the loss of cell-to-cell adhesion, causing the skin to become fragile and blister easily.
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Autoimmune Response
An autoimmune response occurs when the body's immune system mistakenly attacks its own tissues. In pemphigus vulgaris, autoantibodies target proteins in desmosomes, leading to inflammation and damage to the skin, which manifests as blisters and erosions.
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